Bottom line: The inclusion of small studies introduces a whole host of problems with little obvious gain.  So, don’t waste time/money in trying to locate them all.  In most cases less can be more! A recent post in the Lancet [1] caused some controversy by suggesting that systematic reviews can sometimes increase waste by promoting underpowered trials. The authors report: “Efforts by Cochrane and others to locate all … Continue reading Small trials in evidence synthesis